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RU58841 (PSK-3841) is a non-steroidal androgen receptor (AR) antagonist developed to selectively inhibit AR-mediated signaling pathways.
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Voir les résultats d’analyse →RU58841 (PSK-3841) is a non-steroidal androgen receptor (AR) antagonist developed to selectively inhibit AR-mediated signaling pathways. Experimental investigations have demonstrated that RU58841 competes with androgenic ligands for binding to the androgen receptor, preventing receptor activation and downstream transcriptional activity.
Research has examined its interactions with AR-associated regulatory mechanisms, ligand-receptor dynamics, nuclear receptor signaling pathways, and transcriptional control processes governed by androgen receptor activation.
Its well-characterized antagonist profile makes RU58841 a valuable research tool for studies of androgen receptor pharmacology, AR-mediated signal transduction, receptor-ligand competition, nuclear receptor regulation, and comparative investigations of androgen receptor antagonists.
| Chemical Formula | C17H18F3N3O3 |
|---|---|
| Synonyms | PSK-3841, HMR-3841, 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Molar Mass | 369.34 g/mol |
| CAS Number | 154992-24-2 |
| PubChem CID | 132981 |
| Total Compound Content | 5 g powder |
| Shelf Life | 36 months |
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RU58841 was developed as a non-steroidal androgen receptor antagonist for investigations of localized AR-mediated signaling pathways.
Its pharmacological profile has made it a useful research tool for examining androgen receptor activity within defined experimental systems while studying receptor-ligand interactions, androgen-responsive gene regulation, and AR-dependent signal transduction mechanisms. This distinguishes RU58841 from compounds primarily utilized for broader systemic androgen receptor pharmacology studies.
RU58841 exhibits high affinity for the androgen receptor and functions as a competitive antagonist at the AR ligand-binding domain. Experimental studies have utilized RU58841 in receptor-binding assays, ligand competition experiments, and investigations of androgen receptor activation mechanisms.
Its well-characterized antagonist profile makes it a valuable reference compound for comparative studies of androgen receptor pharmacology and receptor-ligand dynamics.
RU58841 powder provides flexibility for preparation in a variety of experimental systems, including receptor-binding assays, cell-based signaling studies, gene expression analyses, and formulation development investigations. The powder format allows researchers to prepare defined concentrations in assay-specific solvents and vehicles, supporting studies of androgen receptor signaling, concentration-response relationships, receptor occupancy, and comparative pharmacological evaluation of AR antagonists.
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