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Orforglipron 6mg / 90caps
Orforglipron is a synthetic, non-peptidic GLP-1 receptor agonist studied in controlled research environments for its role in modulating glucagon-like peptide-1 signalling pathways.
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Laborergebnisse ansehen →Orforglipron is a synthetic, non-peptidic GLP-1 receptor agonist studied in controlled research environments for its role in modulating glucagon-like peptide-1 signalling pathways. Research focuses on its activity in cAMP-dependent pathways, receptor activation dynamics, and peptide-regulated energy balance mechanisms.
Unlike traditional GLP-1 analogues, Orforglipron demonstrates oral bioactivity and high receptor selectivity, making it suitable for experimental models evaluating small molecule agonists in metabolic signalling systems.
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All Apex Peptides products are independently third-party tested at a USA-based HPLC-licensed laboratory prior to distribution. Certificates of Analysis (COA) are published on the Independent Test Results page and available at product level. If any independently conducted HPLC test returns a negative result, Apex Peptides will refund: (1) the cost of the HPLC test, and (2) the full order amount including shipping.
| Chemical Formula | C48H48F2N10O5 |
|---|---|
| Synonyms | LY3502970, OWL833, Foundayo (trade name) |
| Molar Mass | 883.0 g/mol |
| CAS Number | 2212020-52-3 |
| PubChem CID | 137319706 |
| Total Compound Content | 540 mg (6 mg per capsule) |
| Shelf Life | 36 months |
Orforglipron (LY3502970) is a non-peptide small-molecule glucagon-like peptide-1 receptor (GLP-1R) agonist developed as a first-in-class orally active GLP-1R modulator. Unlike peptide-based GLP-1R agonists that bind the receptor's extracellular orthosteric peptide-binding domain, Orforglipron interacts with a distinct binding pocket within the transmembrane region of GLP-1R. This unique binding mechanism enables oral bioavailability while maintaining potent receptor activation. In cellular assays, Orforglipron activates Gs-coupled GLP-1R signalling, stimulating adenylate cyclase activity and increasing intracellular cAMP levels with an EC₅₀ of approximately 3 nM. Selectivity over related class B GPCRs, including the GIP receptor, glucagon receptor, and GLP-2 receptor, has been demonstrated in receptor-screening studies. Research applications include GLP-1 receptor pharmacology, allosteric receptor activation mechanisms, non-peptide GPCR agonist development, receptor conformational biology, ligand-binding studies, and comparative analysis of peptide versus small-molecule GLP-1R agonists. The extended elimination half-life of approximately 29–49 hours makes Orforglipron a useful tool for investigating sustained GLP-1R signalling and long-duration receptor activation. Supplied in 6 mg capsules. Independently third-party HPLC-tested; COA available per batch.
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does Orforglipron's binding mechanism differ from peptide GLP-1R agonists?
Peptide GLP-1R agonists interact primarily with the receptor's extracellular peptide-binding domain, whereas Orforglipron binds within the transmembrane region of GLP-1R through a distinct small-molecule binding site. This alternative binding mode stabilizes an active receptor conformation through a mechanism different from endogenous peptide ligands.
As a result, Orforglipron is a valuable research tool for investigating allosteric receptor activation, receptor conformational dynamics, and the differences between peptide-mediated and small-molecule-mediated GLP-1R signalling.
What advantages does Orforglipron provide for GLP-1R pharmacology research?
As an orally active small-molecule agonist, Orforglipron enables investigation of GLP-1R activation without the structural constraints associated with peptide ligands. This makes it useful for studies examining receptor binding-site architecture, signal-transduction mechanisms, receptor trafficking, ligand-specific signalling profiles, and the development of non-peptide class B GPCR agonists.
Its distinct binding mode also allows direct comparison of orthosteric versus non-orthosteric receptor activation mechanisms.
Why is Orforglipron important for studying GLP-1 receptor signalling?
Orforglipron provides a unique platform for exploring how different ligand classes activate the same receptor. Comparative studies can evaluate receptor activation kinetics, cAMP signalling, receptor internalisation, signalling bias, and conformational changes induced by small-molecule versus peptide agonists. These investigations contribute to a broader understanding of GLP-1R pharmacology and class B GPCR activation mechanisms.
Customer Reviews (9)
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Got the products 2 days after my order with free shipping. So far so good.
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Set up coinbase wallet with there directions. Wasn't that hard. Everything they said was on point on shipping.
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Extremely nice customer service and helpful. I will highly recommend it to my friends.Great product.
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Incredibly fast shipping and the product met all my expectations. A seamless experience from start to finish.
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Highly consistent test results. Very happy with the prompt communication, the chemical quality is top notch. Thanks for the outstanding support!
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Great quality on the secure packaging and the quality is absolutely top-tier. My test results are great. Highly recommend this vendor.
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My test results are great. First-class experience with the ordering process and happy with the quality of this compound. I will definitely be back.
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Cannot recommend enough the prompt communication, quality was great and dispatch was incredibly fast. Excellent all-round service. Our research results are completely exceeding expectations.
