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Pramiracetam is a synthetic pyrrolidinone derivative within the racetam structural class, distinguished from other racetam-family compounds by a diisopropylaminoethyl substituent and reported high lipophilicity.
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Pramiracetam is a synthetic pyrrolidinone derivative within the racetam structural class, distinguished from other racetam-family compounds by a diisopropylaminoethyl substituent and reported high lipophilicity. Research interest centers on its proposed effects on high-affinity choline uptake (HACU) in hippocampal tissue models, a mechanism distinct from direct cholinergic receptor agonism.
Research applications include HACU pathway studies, racetam structure-activity relationship investigation, and comparative pyrrolidinone pharmacology.
| Chemical Formula | C14H27N3O2 |
|---|---|
| Synonyms | Pramiracetam 68497-62-1, Pramiracetam [INN], N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide, UNII-4449F8I3LE |
| Molar Mass | 269.38 g/mol |
| CAS Number | 68497-62-1 |
| PubChem CID | 51712 |
| Total Compound Content | 10 grams |
| Shelf Life | 36 months |
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Pramiracetam is studied for its capacity to enhance the activity of the high-affinity, sodium-dependent choline transporter located on presynaptic cholinergic nerve terminals, which controls the rate-limiting step of choline availability for acetylcholine biosynthesis.
This is a presynaptic transport-modulating mechanism rather than direct activation of muscarinic or nicotinic acetylcholine receptors, distinguishing pramiracetam's research profile from receptor-targeted cholinergic agonists. Synaptosome uptake assays using radiolabeled choline are the standard method for quantifying this effect kinetically (Km, Vmax) under compound exposure.
Pramiracetam shares the 2-oxopyrrolidinone (racetam) core structure common to this compound class but is distinguished by a diisopropylaminoethyl acetamide substituent, which confers substantially higher lipophilicity than simpler racetam-family members. Structure-activity relationship research examining the racetam series often uses pramiracetam as a reference point for how side-chain modifications to the shared pyrrolidinone scaffold influence pharmacological profile, including blood-brain barrier penetration characteristics relevant to CNS-targeted in vivo study design.
Ex vivo hippocampal slice preparations and isolated synaptosome fractions are standard models for studying pramiracetam's effects on cholinergic terminal function, typically measuring choline uptake kinetics directly or acetylcholine release via microdialysis or amperometric methods following compound exposure. Behavioral correlates in rodent models (such as memory-task performance) are sometimes paired with these biochemical measures to connect presynaptic cholinergic effects to functional outcomes, though researchers should treat behavioral and biochemical endpoints as separate lines of evidence requiring independent validation.
There was a small delay with my last order due to the Covid Crisis ongoing at the time but the company was very transparent about it and the package arrived without any further problems. Quality was good. Would order again.
Professional. Good service and product
USPS lost my package and these guys replaced the package immediately without one question.
Product received on time and in great condition :-)
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Our research results have been outstanding. Great experience with the customer service and purity is outstanding. Highly satisfy and will return.
Cannot recommend enough the ordering process and the compound is pure and high quality. Reordering next week. My laboratory research results exceeded expectations.
Great service! Received order fast.
